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Article

Cytochrome P450 in Cancer Susceptibility and Treatment.

Advances in clinical chemistry - 1 Jan 2015

Mittal Balraj, Tulsyan Sonam, Kumar Surendra, Mittal Rama Devi, Agarwal Gaurav

Abstract excerpt

Cytochrome 450 (CYP450) designates a group of enzymes abundant in smooth endoplasmic reticulum of hepatocytes and epithelial cells of small intestines. The main function of CYP450 is oxidative catalysis of various endogenous and exogenous substances. CYP450 are implicated in phase I metabolism of 80% of drugs currently in use, including anticancer drugs. They are also involved in synthesis of various hormones and...

Topics

Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System
Genetic Predisposition to Disease
Humans
Inactivation, Metabolic
Neoplasms
Pharmacogenetics
Polymorphism, Genetic
Treatment Outcome

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PMID: 26411412
DOI: 10.1016/bs.acc.2015.06.003

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