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Article

From Genotype to Phenotype: Content and Activities of Cytochromes P450 2A6 in Human Liver In Vitro and Predicted In Vivo.

The Journal of pharmacology and experimental therapeutics - 1 Mar 2020

Fang Yan, Wang Tong, Guo Yuan-Yuan, Zhang Hai-Feng, Wen Qiang, Xing Yu-Rong, Gao Na, Qiao Hai-Ling

Abstract excerpt

Unraveling the molecular mechanisms by which genetic variants of cytochrome P450 2A6 lead to different metabolic phenotypes remains a long-standing but important challenge. CYP2A6 is an enzyme involved in the metabolism of several clinical drugs as well as the metabolic activation of carcinogenic nitrosamines. Herein, CYP2A6 genotypes and phenotypes, as indicated by protein content [by liquid chromatography-mass...

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Source

Identifiers

PMID: 31882454
DOI: 10.1124/jpet.119.263152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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