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Refining Hepatocyte Models to Capture the Impact of CYP2D6*10 Utilizing a PITCh System.

Biological & pharmaceutical bulletin - 1 Jan 2024

Negoro Ryosuke, Ouchi Ayu, Deguchi Sayaka, Takayama Kazuo, Fujita Takuya

Abstract excerpt

CYP2D6 variants contain various single nucleotide polymorphisms as well as differing levels of metabolic activity. Among these, one of the less active variants CYP2D6*10 (100C > T) is the most prevalent mutation in East Asians, including Japanese. This mutation leads to an amino acid substitution from proline to serine, which reduces the stability of CYP2D6 and consequently decreases its metabolic activity. In...

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PMID: 39111864
DOI: 10.1248/bpb.b24-00202

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