Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population.

doi:10.1038/s41598-021-90969-y

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Article

Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population.

Scientific reports - 11 Jun 2021

Sukprasong Rattanaporn, Chuwongwattana Sumonrat, Koomdee Napatrupron, Jantararoungtong Thawinee, Prommas Santirhat, Jinda Pimonpan, Rachanakul Jiratha, Nuntharadthanaphong Nutthan, Jongjitsook Nutcha, Puangpetch Apichaya, Sukasem Chonlaphat

Abstract excerpt

Prior knowledge of allele frequencies of cytochrome P450 polymorphisms in a population is crucial for the revision and optimization of existing medication choices and doses. In the current study, the frequency of the CYP2C9*2, CYP2C9*3, CYP2C19*2, CYP2C19*3, CYP2C19*6, CYP2C19*17, and CYP3A4 (rs4646437) alleles in a Thai population across different regions of Thailand was examined. Tests for polymorphisms of...

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PMID: 34117307
DOI: 10.1038/s41598-021-90969-y
PMCID: PMC8195986

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