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Article

Distribution Characteristics and Impacting Factors of Drug CYP Enzymes and Transporters in the Gastrointestinal Tract of Chinese Healthy Subjects.

Clinical pharmacology and therapeutics - 1 Mar 2025

Zhang Miao, Zhang Lei, Suo Baojun, Wei Yudong, Xu Yue, Jiang Muhan, Dong Jing, Li Xiaodong, Song Zhiqiang, Liu Dongyang

Abstract excerpt

The abundance of drug metabolic enzymes (DMEs) and transporters (DTs) in the human gastrointestinal tract significantly affects xenobiotic exposure in the circulating system, the basis of these compounds acting on humans. However, accurately predicting individual exposure in healthy subjects remains challenging due to limited data on protein levels throughout the gastrointestinal tract within the same individuals...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39582241
DOI: 10.1002/cpt.3497

Genes

CYP2C9
CYP3A4
CYP2C19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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