Article
Genetic polymorphisms of cytochrome P450 in patients with hepatitis C virus-associated hepatocellular carcinoma.
Journal of gastroenterology and hepatology - 1 Aug 2005
Mochizuki Junko, Murakami Shigeto, Sanjo Akira, Takagi Ichiro, Akizuki Setsuko, Ohnishi Akihiro
Abstract excerpt
BACKGROUND: The carcinogenic process can be modulated by exposure to endogenous or environmental substance(s) acting as carcinogens or protocarcinogens. Polymorphic enzymes of cytochrome P450 (CYP) that play a role in detoxication/toxication of such substances via metabolization may account for the interpatient variability of clinical course in cancers such as hepatocellular carcinoma (HCC). Many CYP genetic...
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