Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer.

doi:10.1038/ng.3573

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Article

Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer.

Nature genetics - 1 Jul 2016

McPherson Andrew, Roth Andrew, Laks Emma, Masud Tehmina, Bashashati Ali, Zhang Allen W, Ha Gavin, Biele Justina, Yap Damian, Wan Adrian, Prentice Leah M, Khattra Jaswinder, Smith Maia A, Nielsen Cydney B, Mullaly Sarah C, Kalloger Steve, Karnezis Anthony, Shumansky Karey, Siu Celia, Rosner Jamie, Chan Hector Li, Ho Julie, Melnyk Nataliya, Senz Janine, Yang Winnie, Moore Richard, Mungall Andrew J, Marra Marco A, Bouchard-Côté Alexandre, Gilks C Blake, Huntsman David G, McAlpine Jessica N, Aparicio Samuel, Shah Sohrab P

Abstract excerpt

We performed phylogenetic analysis of high-grade serous ovarian cancers (68 samples from seven patients), identifying constituent clones and quantifying their relative abundances at multiple intraperitoneal sites. Through whole-genome and single-nucleus sequencing, we identified evolutionary features including mutation loss, convergence of the structural genome and temporal activation of mutational processes that...

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PMID: 27182968
DOI: 10.1038/ng.3573

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