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Article

Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis.

PLoS medicine - 1 Feb 2015

Schwarz Roland F, Ng Charlotte K Y, Cooke Susanna L, Newman Scott, Temple Jillian, Piskorz Anna M, Gale Davina, Sayal Karen, Murtaza Muhammed, Baldwin Peter J, Rosenfeld Nitzan, Earl Helena M, Sala Evis, Jimenez-Linan Mercedes, Parkinson Christine A, Markowetz Florian, Brenton James D

Abstract excerpt

BACKGROUND: The major clinical challenge in the treatment of high-grade serous ovarian cancer (HGSOC) is the development of progressive resistance to platinum-based chemotherapy. The objective of this study was to determine whether intra-tumour genetic heterogeneity resulting from clonal evolution and the emergence of subclonal tumour populations in HGSOC was associated with the development of resistant disease....

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Identifiers

PMID: 25710373
DOI: 10.1371/journal.pmed.1001789
PMCID: PMC4339382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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