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Article

Dualistic classification of high grade serous ovarian carcinoma has its root in spatial heterogeneity.

Journal of advanced research - 1 Jun 2023

Sun Tingting, Zhang Zuwei, Tian Liming, Zheng Yu, Wu Linxiang, Guo Yunyun, Li Xiaohui, Li Yuanyuan, Shen Hongwei, Lai Yingrong, Liu Junfeng, Cui Huanhuan, He Shasha, Ren Yufeng, Yang Guofen

Abstract excerpt

INTRODUCTION: Widespread intra-peritoneal metastases is a main feature of high grade serous ovarian carcinoma (HGSOC). Recently, the extent of tumour heterogeneity was used to evaluate the cancer genomes among multi-regions in HGSOC. However, there is no consensus on the effect of tumour heterogeneity on the evolution of the tumour metastasis process in HGSOC. OBJECTIVES: We performed whole-exome sequencing in...

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Identifiers

PMID: 36038111
DOI: 10.1016/j.jare.2022.08.014
PMCID: PMC10248863

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