Article

The interface of malignant and immunologic clonal dynamics in high-grade serous ovarian cancer

2017-10-04

Abstract excerpt

<h4>Summary</h4> High-grade serous ovarian cancer exhibits extensive intratumoral heterogeneity coupled with widespread intraperitoneal disease. Despite this, metastatic spread of tumor clones is non-random, implying the existence of local microenvironmental factors that shape tumor progression. We interrogated the molecular interface between tumor-infiltrating lymphocytes (TIL) and cancer cells in 143 samples fr...

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Literature Corpus work: ade2b667-f2d8-5260-9b03-c5dd5509397d
DOI: 10.1101/198101

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