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Article

Clonality, Heterogeneity, and Evolution of Synchronous Bilateral Ovarian Cancer.

Cancer research - 1 Dec 2017

Yin Xia, Jing Ying, Cai Mei-Chun, Ma Pengfei, Zhang Yi, Xu Cong, Zhang Meiying, Di Wen, Zhuang Guanglei

Abstract excerpt

Synchronous bilateral ovarian cancer (SBOC) represents a relatively frequent occurrence and clinically relevant diagnostic dilemma. Delineation of its clonal architecture, genetic heterogeneity, and evolutionary trajectories may have important implications for prognosis and management of patients with SBOC. Here, we describe the results of next-generation whole-exome or whole-genome sequencing of specimens from...

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PMID: 28972072
DOI: 10.1158/0008-5472.CAN-17-1461

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