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Genetic heterogeneity and evolutionary history of high-grade ovarian carcinoma and matched distant metastases

25 Feb 2020

Abstract excerpt

BACKGROUND: High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian carcinoma, associated with poor clinical outcome and metastatic disease. Although metastatic processes are becoming more understandable, the genomic landscape and metastatic progression in HGSOC has not been elucidated. METHODS: Multi-region whole-exome sequencing was performed on HGSOC primary tumours and their...

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PMID: 32099096
DOI: 10.1038/s41416-020-0763-4

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