Article

Evolutionary states and trajectories characterized by distinct pathways stratify ovarian high-grade serous carcinoma patients

2022-09-01

Abstract excerpt

<h4>ABSTRACT</h4> Ovarian high-grade serous carcinoma (HGSC) is typically diagnosed at an advanced stage, with multiple genetically heterogeneous clones existing in the tumors long before therapeutic intervention. Herein we characterized HGSC evolutionary states using whole-genome sequencing data from 214 samples of 55 HGSC patients in the prospective, longitudinal, multiregion DECIDER study. Comparison of the ti...

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Literature Corpus work: 6009928d-4445-5dbc-a35e-2f00b3d63f5d
DOI: 10.1101/2022.08.30.505808

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