Article
Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling.
The Journal of pathology - 1 Sept 2013
Bashashati Ali, Ha Gavin, Tone Alicia, Ding Jiarui, Prentice Leah M, Roth Andrew, Rosner Jamie, Shumansky Karey, Kalloger Steve, Senz Janine, Yang Winnie, McConechy Melissa, Melnyk Nataliya, Anglesio Michael, Luk Margaret T Y, Tse Kane, Zeng Thomas, Moore Richard, Zhao Yongjun, Marra Marco A, Gilks Blake, Yip Stephen, Huntsman David G, McAlpine Jessica N, Shah Sohrab P
Abstract excerpt
High-grade serous ovarian cancer (HGSC) is characterized by poor outcome, often attributed to the emergence of treatment-resistant subclones. We sought to measure the degree of genomic diversity within primary, untreated HGSCs to examine the natural state of tumour evolution prior to therapy. We performed exome sequencing, copy number analysis, targeted amplicon deep sequencing and gene expression profiling on 31...
Topics
Join the communities discussing this publication.