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Article

Single cell-derived spheroids capture the self-renewing subpopulations of metastatic ovarian cancer

29 Nov 2021

Abstract excerpt

High Grade Serous Ovarian cancer (HGSOC) is a major unmet need in oncology, due to its precocious dissemination and the lack of meaningful human models for the investigation of disease pathogenesis in a patient-specific manner. To overcome this roadblock, we present a new method to isolate and grow single cells directly from patients' metastatic ascites, establishing the conditions for propagating them as 3D...

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PMID: 34845371
DOI: 10.1038/s41418-021-00878-w

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