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Article

Integrated Single-Cell Whole-Genome Sequencing and Spatial Transcriptomics Reveal Intratumoral Heterogeneity in Ovarian Cancer.

Cancer research communications - 1 May 2026

Bassiouni Rania, Jin Yuxin, Gibbs Lee D, Qian Jing, Rotimi Solomon O, Miller Heather, Webb Michelle G, Rajpara Seeta, Arias-Stella Javier, Craig David W, Roman Lynda, Carpten John D

Abstract excerpt

The mortality rate of ovarian cancer remains disproportionately high compared with its incidence. This is partly due to a high level of intratumoral heterogeneity, driven by genomic instability, that promotes disease recurrence and treatment failure. In this study, we describe degrees of heterogeneity revealed by single-cell whole-genome sequencing and spatial transcriptomics (ST) of five late-stage,...

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Identifiers

PMID: 42007974
DOI: 10.1158/2767-9764.CRC-25-0795
PMCID: PMC13137417

Genes

CTNNB1

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