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Article

Evolutionary mode and timing of dissemination of high-grade serous carcinomas.

JCI insight - 4 Jan 2024

Sveen Anita, Johannessen Bjarne, Klokkerud Solveig Mk, Kraggerud Sigrid M, Meza-Zepeda Leonardo A, Bjørnslett Merete, Bischof Katharina, Myklebost Ola, Taskén Kjetil, Skotheim Rolf I, Dørum Anne, Davidson Ben, Lothe Ragnhild A

Abstract excerpt

Dissemination within the peritoneal cavity is a main determinant of poor patient outcomes from high-grade serous carcinomas (HGSCs). The dissemination process is poorly understood from a cancer evolutionary perspective. We reconstructed the evolutionary trajectories across a median of 5 tumor sites and regions from each of 23 patients based on deep whole-exome sequencing. Polyclonal cancer origin was detected in...

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Identifiers

PMID: 38175731
DOI: 10.1172/jci.insight.170423
PMCID: PMC11143962

Genes

AKT1
BRCA1
BRCA2
DNMT3A
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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