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Evolutionary states and trajectories characterized by distinct pathways stratify patients with ovarian high grade serous carcinoma

18 May 2023

Abstract excerpt

Ovarian high-grade serous carcinoma (HGSC) is typically diagnosed at an advanced stage, with multiple genetically heterogeneous clones existing in the tumors long before therapeutic intervention. Herein we integrate clonal composition and topology using whole-genome sequencing data from 510 samples of 148 patients with HGSC in the prospective, longitudinal, multiregion DECIDER study. Our results reveal three...

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PMID: 37207655
DOI: 10.1016/j.ccell.2023.04.017

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