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Article

Expression of A152T human tau causes age‐dependent neuronal dysfunction and loss in transgenic mice

1 Mar 2016

Abstract excerpt

A152T‐variant human tau (hTau‐A152T) increases risk for tauopathies, including Alzheimer's disease. Comparing mice with regulatable expression of hTau‐A152T or wild‐type hTau (hTau‐WT), we find age‐dependent neuronal loss, cognitive impairments, and spontaneous nonconvulsive epileptiform activity primarily in hTau‐A152T mice. However, overexpression of either hTau species enhances neuronal responses to electrical...

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PMID: 26931567
DOI: 10.15252/embr.201541438

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