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Article

Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits.

The American journal of pathology - 1 Aug 2006

Schindowski Katharina, Bretteville Alexis, Leroy Karelle, Bégard Séverine, Brion Jean-Pierre, Hamdane Malika, Buée Luc

Abstract excerpt

Tau transgenic mice are valuable models to investigate the role of tau protein in Alzheimer's disease and other tauopathies. However, motor dysfunction and dystonic posture interfering with behavioral testing are the most common undesirable effects of tau transgenic mice. Therefore, we have generated a novel mouse model (THY-Tau22) that expresses human 4-repeat tau mutated at sites G272V and P301S under a...

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Identifiers

PMID: 16877359
DOI: 10.2353/ajpath.2006.060002
PMCID: PMC1698785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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