Article

Reducing tau ameliorates behavioural and transcriptional deficits in a novel model of Alzheimer’s disease

2018-08-16

Abstract excerpt

<h4>Summary</h4> One of the key knowledge gaps blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) and tau cooperate in causing disease phenotypes. Within a mouse tau deficient background, we probed the molecular, cellular and behavioural disruption triggered by wild-type human tau’s influence on human Aβ-induced pathology. We find that...

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Literature Corpus work: 8ac32796-7304-5827-a8bb-fcaee716e376
DOI: 10.1101/393405

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