Article
Tau reduction with artificial microRNAs modulates neuronal physiology and improves tauopathy phenotypes in mice.
Molecular therapy : the journal of the American Society of Gene Therapy - 3 Apr 2024
Facal Carolina Lucía, Fernández Bessone Iván, Muñiz Javier Andrés, Pereyra A Ezequiel, Pedroncini Olivia, Páez-Paz Indiana, Clerici-Delville Ramiro, Arnaiz Cayetana, Urrutia Leandro, Falasco Germán, Argañaraz Carla Verónica, Saez Trinidad, Marin-Burgin Antonia, Soiza-Reilly Mariano, Falzone Tomás, Avale María Elena
Abstract excerpt
Abnormal tau accumulation is the hallmark of several neurodegenerative diseases, named tauopathies. Strategies aimed at reducing tau in the brain are promising therapeutic interventions, yet more precise therapies would require targeting specific nuclei and neuronal subpopulations affected by disease while avoiding global reduction of physiological tau. Here, we developed artificial microRNAs directed against the...
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