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Article

Antisense Reduction of Tau in Adult Mice Protects against Seizures

31 Jul 2013

Abstract excerpt

Tau, a microtubule-associated protein, is implicated in the pathogenesis of Alzheimer's Disease (AD) in regard to both neurofibrillary tangle formation and neuronal network hyperexcitability. The genetic ablation of tau substantially reduces hyperexcitability in AD mouse lines, induced seizure models, and genetic in vivo models of epilepsy. These data demonstrate that tau is an important regulator of network...

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PMID: 23904623
DOI: 10.1523/jneurosci.2107-13.2013

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