Article

Humanized tau and amyloid-β deposition accelerate tau propagation, neuronal cell loss and neurophysiological dysfunction in novel mouse models of primary age-related tauopathy and Alzheimer’s disease

2026-02-24

Abstract excerpt

In Alzheimer’s disease (AD), tau pathology arises in entorhinal cortex layer II (ECII) and advances through defined hippocampal circuits to CA1 and connected neocortical regions, yet the determinants of this hierarchical spread remain unclear. We previously established a circuit-defined propagation model by expressing Cre-inducible human P301L 2N4R tau selectively in Wolframin-1 (Wfs1) + ECII neurons using AAV-FL...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b5800e9f-bb38-5291-a0b2-6a8537102552
DOI: 10.64898/2026.02.23.707081

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Humanized tau and amyloid-β deposition accelerate tau propagation, neuronal cell loss and neurophysiological dysfunction in novel mouse models of primary age-related tauopathy and Alzheimer’s diseaseDOI 10.64898/2026.02.23.707081Read

Propagation of tau pathology in a model of early Alzheimer's disease.Semantic proximity Read

Differential neural circuit vulnerability to β-amyloid and tau pathologies in novel Alzheimer’s disease miceSemantic proximity Read

Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.Semantic proximity Read

Insights From TgF344-AD, a Double Transgenic Rat Model in Alzheimer’s Disease ResearchSemantic proximity Read

Endogenous pathology in tauopathy mice progresses via brain networksSemantic proximity Read

Spreading of Tau Protein Does Not Depend on Aggregation PropensitySemantic proximity Read

Patient-derived tau-seeded human neuronal chimeras recapitulate mature Alzheimer’s tau pathology and uncover human-specific neuronal vulnerabilitySemantic proximity Read

Aberrant medial entorhinal cortex dynamics link tau pathology to spatial memory impairmentSemantic proximity Read

Preferential generation of pathological tau species in specific subtypes of entorhinal neurons: implications for Alzheimer’s DiseaseSemantic proximity Read

Tau pathology spreads between anatomically-connected regions of the brain and is modulated by a LRRK2 mutationSemantic proximity Read

Single <i>MAPT</i> knock-in mouse models of frontotemporal dementia for sharing with the neurodegenerative research communitySemantic proximity Read

Cell-type specific profiling of human entorhinal cortex at the onset of Alzheimer’s disease neuropathologySemantic proximity Read