Article

Patient-derived tau-seeded human neuronal chimeras recapitulate mature Alzheimer’s tau pathology and uncover human-specific neuronal vulnerability

2026-07-08

Abstract excerpt

Tau pathology is a central hallmark of Alzheimer’s disease (AD) and strongly correlates with cognitive decline, yet the development of tau-targeted therapies has been hindered by the inability of existing models to capture human-specific disease features, particularly the mature forms of AD tau pathology. Moreover, species-specific mechanisms underlying tau pathology remain poorly understood. Here, we establish a...

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Literature Corpus work: b4023902-cb81-5c46-b0b0-f6a74433939c
DOI: 10.64898/2026.07.06.736894

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