Article

A conserved serotonin receptor pathway is a druggable modifier of Tau pathology, neural circuit formation and neurodegeneration

2026-08-27

Abstract excerpt

<h4>Background</h4> Tauopathies are devastating neurodegenerative disorders characterized by Tau hyperphosphorylation, neurofibrillary tangle (NFT) formation, neuronal dysfunction, and cognitive decline. <h4>Methods</h4> Here, we establish a new Drosophila tauopathy model expressing eGFP-tagged human Tau WT or the disease-associated Tau P301L variant in the nervous system. <h4>Results</h4> Tau P301L express...

Topics

Open a Topic to create a Post that cites this publication.

Uncategorized literature

Identifiers and source

Literature Corpus work: 318bf744-818a-5248-bebe-32ac68670752
DOI: 10.64898/2026.08.24.746720

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

A conserved serotonin receptor pathway is a druggable modifier of Tau pathology, neural circuit formation and neurodegenerationDOI 10.64898/2026.08.24.746720Read

The <i>Drosophila</i> wing is a high-throughput and versatile screening tool for Tau-mediated disease mechanisms and drug discoverySemantic proximity Read

Differential effects of Tau on the integrity and function of neurons essential for learning in Drosophila.Semantic proximity Read

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles.Semantic proximity Read

Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a <i>Drosophila</i> knock-in tauopathy modelSemantic proximity Read

Context-dependent toxicity of human Tau isoforms in a <i>Drosophila</i> tauopathy modelSemantic proximity Read

Sexually dimorphic behavioural signatures of tau toxicity in adult <i>Drosophila</i>Semantic proximity Read

Drosophila wing is a high-throughput and versatile screening tool for Tau-mediated disease mechanisms and drug discovery.Semantic proximity Read

Drosophila Models of Tauopathies: What Have We Learned?Semantic proximity Read

Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation.Semantic proximity Read

Loss of Tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila.Semantic proximity Read

Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)Semantic proximity Read

Human iPSC 4R tauopathy model uncovers modifiers of tau propagationSemantic proximity Read