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Article

A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics.

Experimental neurology - 1 Jul 2008

Rosenmann Hanna, Grigoriadis Nikolaos, Eldar-Levy Hila, Avital Avi, Rozenstein Lea, Touloumi Olga, Behar Leah, Ben-Hur Tamir, Avraham Yosefa, Berry Eliot, Segal Menahem, Ginzburg Irith, Abramsky Oded

Abstract excerpt

The neurofibrillary-tangles (NTFs), characteristic of tauopathies including Alzheimer's-disease (AD), are the pathological features which correlate best with dementia. The objective of our study was to generate an authentic transgenic (tg) animal model for NFT pathology in tauopathy/AD. Previous NFT-tg mice were driven by non-related/non-homologous promoters. Our strategy was to use the natural tau promoter for...

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PMID: 18490011
DOI: 10.1016/j.expneurol.2008.03.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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