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Article

Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD.

Acta neuropathologica communications - 25 Feb 2016

Sydow Astrid, Hochgräfe Katja, Könen Stefanie, Cadinu Daniela, Matenia Dorthe, Petrova Olga, Joseph Maria, Dennissen Frank Johannes, Mandelkow Eva-Maria

Abstract excerpt

INTRODUCTION: Mutations of Tau are associated with several neurodegenerative disorders. Recently, the Tau mutation A152T was described as a novel risk factor for frontotemporal dementia spectrum disorders and Alzheimer disease. In vitro Tau-A152T shows a decreased binding to microtubules and a reduced tendency to form abnormal fibers. RESULTS: To study the effects of this mutation we generated a mouse model...

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PMID: 26916334
DOI: 10.1186/s40478-016-0281-z
PMCID: PMC4766625

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