Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity.

EMBO reports - 1 Apr 2016

Decker Jochen Martin, Krüger Lars, Sydow Astrid, Dennissen Frank Ja, Siskova Zuzana, Mandelkow Eckhard, Mandelkow Eva-Maria

Abstract excerpt

We report on a novel transgenic mouse model expressing human full-length Tau with the Tau mutation A152T (hTau(AT)), a risk factor for FTD-spectrum disorders including PSP and CBD Brain neurons reveal pathological Tau conformation, hyperphosphorylation, mis-sorting, aggregation, neuronal degeneration, and progressive loss, most prominently in area CA3 of the hippocampus. The mossy fiber pathway shows enhanced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Culture Media
Share to Frontotemporal Dementia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamic Acid

Share to Neuronal Plasticity

Share to Organ Culture Techniques

Share to Receptors, N-Methyl-D-Aspartate

Share to Synaptic Transmission

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26931569
DOI: 10.15252/embr.201541439
PMCID: PMC4818782

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity.PMID 26931569Read ↗

Expression of A152T human tau causes age‐dependent neuronal dysfunction and loss in transgenic miceSemantic proximity Read ↗

Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD.Semantic proximity Read ↗

Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits.Semantic proximity Read ↗

Humanized tau and amyloid-β deposition accelerate tau propagation, neuronal cell loss and neurophysiological dysfunction in novel mouse models of primary age-related tauopathy and Alzheimer’s diseaseSemantic proximity Read ↗

Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.Semantic proximity Read ↗

A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics.Semantic proximity Read ↗

Presynaptic Pathophysiology Encoded in Different Domains of Tau - Hyper-Versus Hypoexcitability?Semantic proximity Read ↗

STAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP-17Semantic proximity Read ↗

Glutamatergic nervous system degeneration in a C. elegans TauA152T tauopathy model involves pathways of excitotoxicity and Ca2+ dysregulationSemantic proximity Read ↗

Selective reduction of <i>KCNA4</i> in vulnerable glutamatergic-serotonin neurons of the dorsal raphe nucleus in Alzheimer’s DiseaseSemantic proximity Read ↗

Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer’s diseaseSemantic proximity Read ↗

Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.