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Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate

12 Jun 2016

Abstract excerpt

Human neurodegenerative tauopathies exhibit pathological tau aggregates in the brain along with diverse clinical features including cognitive and motor dysfunction. Post-translational modifications including phosphorylation, ubiquitination and truncation, are characteristic features of tau present in the brain in human tauopathy. We have previously reported an N-terminally truncated form of tau in human brain...

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PMID: 27297240
DOI: 10.1093/brain/aww137

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