Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children.

The pharmacogenomics journal - 1 Mar 2017

Chidambaran V, Venkatasubramanian R, Zhang X, Martin L J, Niu J, Mizuno T, Fukuda T, Meller J, Vinks A A, Sadhasivam S

Abstract excerpt

Respiratory depression (RD) is a serious side effect of morphine and detrimental to effective analgesia. We reported that variants of the ATP binding cassette gene ABCC3 (facilitates hepatic morphine metabolite efflux) affect morphine metabolite clearance. In this study of 316 children undergoing tonsillectomy, we found significant association between ABCC3 variants and RD leading to prolonged postoperative care...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analgesics, Opioid
Share to Glucuronides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Metabolic Clearance Rate

Share to Morphine

Share to Pain, Postoperative

Share to Respiration

Share to Respiratory Insufficiency

Source

Open in PubMed Open full text

Identifiers

PMID: 26810133
DOI: 10.1038/tpj.2015.98
PMCID: PMC4959996

Genes

ABCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children.PMID 26810133Read ↗

Opioid-induced respiratory depression: ABCB1 transporter pharmacogenetics.Semantic proximity Read ↗

ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children.Semantic proximity Read ↗

Codeine and opioid metabolism: implications and alternatives for pediatric pain management.Semantic proximity Read ↗

Novel associations between FAAH genetic variants and postoperative central opioid-related adverse effects.Semantic proximity Read ↗

TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population.Semantic proximity Read ↗

Novel associations between CYP2B6 polymorphisms, perioperative methadone metabolism and clinical outcomes in children.Semantic proximity Read ↗

Is ethnicity associated with morphine's side effects in children? Morphine pharmacokinetics, analgesic response, and side effects in children having tonsillectomy.Semantic proximity Read ↗

Putative association of ABCB1 2677G>T/A with oxycodone-induced central nervous system depression in breastfeeding mothers.Semantic proximity Read ↗

ABCB1 genotype is associated with fentanyl requirements in critically ill children.Semantic proximity Read ↗

The rs776746 variant of CYP3A5 is associated with intravenous midazolam plasma levels and higher clearance in critically ill Mexican paediatric patients.Semantic proximity Read ↗

Fatty acid amide hydrolase-morphine interaction influences ventilatory response to hypercapnia and postoperative opioid outcomes in children.Semantic proximity Read ↗

Genetic polymorphisms in the ABCB1 gene and the effects of fentanyl in Koreans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.