Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children.

Pharmacogenomics - 1 Jul 2014

Venkatasubramanian Raja, Fukuda Tsuyoshi, Niu Jing, Mizuno Tomoyuki, Chidambaran Vidya, Vinks Alexander A, Sadhasivam Senthilkumar

Abstract excerpt

AIM: Large interindividual variability in morphine pharmacokinetics could contribute to variability in morphine analgesia and adverse events. METHODS: Influence of weight, genetic polymorphisms, race and sex on morphine clearance and metabolite formation from 220 children undergoing outpatient adenotonsillectomy was studied. A nonlinear mixed effects model was developed in NONMEM to describe morphine and morphine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Child
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Morphine

Share to Multidrug Resistance-Associated Proteins

Share to Organic Cation Transporter 1

Share to Pain, Postoperative

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 25155932
DOI: 10.2217/pgs.14.99
PMCID: PMC4190075

Genes

ABCC3
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children.PMID 25155932Read ↗

OCT1 genetic variants influence the pharmacokinetics of morphine in children.Semantic proximity Read ↗

ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children.Semantic proximity Read ↗

Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter.Semantic proximity Read ↗

Influence of OCT 1 Ontogeny and Genetic Variation on Morphine Disposition in Critically Ill Neonates: Lessons From PBPK Modeling and Clinical StudySemantic proximity Read ↗

Morphine clearance in children: does race or genetics matter?Semantic proximity Read ↗

Lack of genetic association between OCT1, ABCB1, and UGT2B7 variants and morphine pharmacokinetics.Semantic proximity Read ↗

No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients.Semantic proximity Read ↗

Is ethnicity associated with morphine's side effects in children? Morphine pharmacokinetics, analgesic response, and side effects in children having tonsillectomy.Semantic proximity Read ↗

Influence of MRP3 Genetics and Hepatic Expression Ontogeny for Morphine Disposition in Neonatal and Pediatric Patients.Semantic proximity Read ↗

OCT1 pharmacogenetics in pain management: is a clinical application within reach?Semantic proximity Read ↗

Effect of CYP3A5 and CYP3A4 Genetic Variants on Fentanyl Pharmacokinetics in a Pediatric Population.Semantic proximity Read ↗

TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.