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Article

Putative association of ABCB1 2677G>T/A with oxycodone-induced central nervous system depression in breastfeeding mothers.

Therapeutic drug monitoring - 1 Aug 2013

Lam Jessica, Kelly Lauren, Matok Ilan, Ross Colin J D, Carleton Bruce C, Hayden Michael R, Madadi Parvaz, Koren Gideon

Abstract excerpt

OBJECTIVE: To assess the effect of maternal CYP2D6, CYP3A5, ABCB1, and OPRM1 polymorphisms in predicting both neonatal and maternal central nervous system depression after oxycodone use during lactation. STUDY DESIGN: A nested case-control study in 67 breastfeeding mother-infant pairs exposed to oxycodone was conducted. Cases were defined as parental reports of lethargy in the infant temporally related to...

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Identifiers

PMID: 23783165
DOI: 10.1097/FTD.0b013e318288f158

Genes

ABCB1
OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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