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Article

Opioid-induced respiratory depression: ABCB1 transporter pharmacogenetics.

The pharmacogenomics journal - 1 Apr 2015

Sadhasivam S, Chidambaran V, Zhang X, Meller J, Esslinger H, Zhang K, Martin L J, McAuliffe J

Abstract excerpt

Opioid-related respiratory depression (RD) is a serious clinical problem as it causes multiple deaths and anoxic brain injuries. Morphine is subject to efflux via P-glycoprotein transporter encoded by ABCB1, also known as MDR1. ABCB1 polymorphisms may affect blood-brain barrier transport of morphine and therefore individual response to its central analgesic and adverse effects. This study aimed to determine...

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Share to Analgesics, Opioid
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25311385
DOI: 10.1038/tpj.2014.56

Genes

ABCB1

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