Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ABCB1 genotype is associated with fentanyl requirements in critically ill children.

Pediatric research - 1 Jul 2017

Horvat Christopher M, Au Alicia K, Conley Yvette P, Kochanek Patrick M, Li Lingjue, Poloyac Samuel M, Empey Philip E, Clark Robert S B

Abstract excerpt

BackgroundThe gene ABCB1 encodes p-glycoprotein, a xenobiotic efflux pump capable of transporting certain opioids, including fentanyl. ABCB1 genotype has been previously associated with patient opioid requirements and may influence fentanyl dosing requirements in critically ill children.MethodsA diagnostically diverse cohort of 61 children who received a fentanyl infusion while admitted to the pediatric intensive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analgesics, Opioid
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Critical Illness

Share to Drug Administration Schedule

Share to Fentanyl

Share to Multivariate Analysis

Share to Pain Management

Source

Open in PubMed Open full text

Identifiers

PMID: 28388599
DOI: 10.1038/pr.2017.103
PMCID: PMC5509475

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ABCB1 genotype is associated with fentanyl requirements in critically ill children.PMID 28388599Read ↗

Opioid-induced respiratory depression: ABCB1 transporter pharmacogenetics.Semantic proximity Read ↗

ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children.Semantic proximity Read ↗

Genetic polymorphisms in the ABCB1 gene and the effects of fentanyl in Koreans.Semantic proximity Read ↗

Morphine clearance in children: does race or genetics matter?Semantic proximity Read ↗

Association between ABCB1 gene polymorphisms and fentanyl's adverse effects in Turkish patients undergoing spinal anesthesia.Semantic proximity Read ↗

Effect of CYP3A5 and CYP3A4 Genetic Variants on Fentanyl Pharmacokinetics in a Pediatric Population.Semantic proximity Read ↗

ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children.Semantic proximity Read ↗

Codeine and opioid metabolism: implications and alternatives for pediatric pain management.Semantic proximity Read ↗

Influence of OCT 1 Ontogeny and Genetic Variation on Morphine Disposition in Critically Ill Neonates: Lessons From PBPK Modeling and Clinical StudySemantic proximity Read ↗

Can pharmacogenetics inform morphine dosing in the neonatal intensive care unit? A retrospective evaluation.Semantic proximity Read ↗

ABCB1 genetic polymorphisms affect opioid requirement by altering function of the intestinal P-glycoprotein.Semantic proximity Read ↗

Is ethnicity associated with morphine's side effects in children? Morphine pharmacokinetics, analgesic response, and side effects in children having tonsillectomy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.