Article
Codeine and opioid metabolism: implications and alternatives for pediatric pain management.
Current opinion in anaesthesiology - 1 Jun 2017
Chidambaran Vidya, Sadhasivam Senthilkumar, Mahmoud Mohamed
Abstract excerpt
PURPOSE OF REVIEW: Use of perioperative opioids for surgical pain management of children presents clinical challenges because of concerns of serious adverse effects including life-threatening respiratory depression. This is especially true for children with history of obstructive sleep apnea. This review will explore current knowledge of clinically relevant factors and genetic polymorphisms that affect opioid...
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