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Article

Is ethnicity associated with morphine's side effects in children? Morphine pharmacokinetics, analgesic response, and side effects in children having tonsillectomy.

Paediatric anaesthesia - 1 Jul 2012

Jimenez Nathalia, Anderson Gail D, Shen Danny D, Nielsen Susan S, Farin Federico M, Seidel Kristy, Lynn Anne M

Abstract excerpt

OBJECTIVES/AIMS: To examine whether morphine pharmacokinetics (PK) and/or genetic polymorphisms in opioid-related genes, underlie differences in analgesic response and side effects to morphine in Latino (L) vs non-Latino Caucasian (NL) children. BACKGROUND: Morphine has high interindividual variability in its analgesic response and side effects profile. Earlier studies suggest that morphine response may vary by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22486937
DOI: 10.1111/j.1460-9592.2012.03844.x
PMCID: PMC3366036

Genes

ABCB1
ARRB2
COMT
OPRM1
STAT6

Provenance

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