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Article

Fatty acid amide hydrolase-morphine interaction influences ventilatory response to hypercapnia and postoperative opioid outcomes in children.

Pharmacogenomics - 1 Jan 2017

Chidambaran Vidya, Pilipenko Valentina, Spruance Kristie, Venkatasubramanian Raja, Niu Jing, Fukuda Tsuyoshi, Mizuno Tomoyuki, Zhang Kejian, Kaufman Kenneth, Vinks Alexander A, Martin Lisa J, Sadhasivam Senthilkumar

Abstract excerpt

AIM: Fatty acid amide hydrolase (FAAH) degrades anandamide, an endogenous cannabinoid. We hypothesized that FAAH variants will predict risk of morphine-related adverse outcomes due to opioid-endocannabinoid interactions. PATIENTS & METHODS: In 101 postsurgical adolescents receiving morphine analgesia, we prospectively studied ventilatory response to 5% CO2 (HCVR), respiratory depression (RD) and vomiting. Blood...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27977335
DOI: 10.2217/pgs-2016-0147
PMCID: PMC5558540

Genes

FAAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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