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Article

The rs776746 variant of CYP3A5 is associated with intravenous midazolam plasma levels and higher clearance in critically ill Mexican paediatric patients.

Journal of clinical pharmacy and therapeutics - 1 Jun 2021

Flores-Pérez Carmen, Castillejos-López Manuel de Jesús, Chávez-Pacheco Juan Luis, Dávila-Borja Víctor Manuel, Flores-Pérez Janett, Zárate-Castañón Patricia, Acosta-Bastidas Mario, Cruz-Escobar Jonathan, Torres-Espíndola Luz María

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVE: Midazolam is a drug that is metabolized by cytochrome P450 (CYP450) enzymes, particularly CYP3A4 and CYP3A5. The presence of single-nucleotide polymorphisms (SNPs) in the genes encoding these enzymes, such as CYP3A4*1B which is associated with low enzyme expression and activity and CYP3A5*3, has been associated with decrease in enzymatic activity and reduced drug clearance, with...

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Identifiers

PMID: 33638195
DOI: 10.1111/jcpt.13388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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