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Article

Novel associations between CYP2B6 polymorphisms, perioperative methadone metabolism and clinical outcomes in children.

Pharmacogenomics - 1 Jul 2021

Packiasabapathy Senthil, Aruldhas Blessed W, Zhang Pengyue, Overholser Brian R, Quinney Sara K, Sadhasivam Senthilkumar

Abstract excerpt

Aim: Methadone exhibits significant variability in clinical response. This study explores the genetic influence of variable methadone pharmacokinetics. Methods: This is a prospective study of methadone in children undergoing major surgery. CYP2B6 genotyping, plasma methadone and metabolite levels were obtained. Clinical outcomes include pain scores and postoperative nausea and vomiting (PONV). Results:CYP2B6 poor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2B6

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Source

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Identifiers

PMID: 34100292
DOI: 10.2217/pgs-2021-0039
PMCID: PMC8238023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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