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Article

Novel associations between FAAH genetic variants and postoperative central opioid-related adverse effects.

The pharmacogenomics journal - 1 Oct 2015

Sadhasivam S, Zhang X, Chidambaran V, Mavi J, Pilipenko V, Mersha T B, Meller J, Kaufman K M, Martin L J, McAuliffe J

Abstract excerpt

Opioid effects are potentiated by cannabinoid agonists including anandamide, an endocannabinoid. Inter-individual variability in responses to opioids is a major clinical problem. Multiple deaths and anoxic brain injuries occur every year because of opioid-induced respiratory depression (RD) in surgical patients and drug abusers of opioids and cannabinoids. This study aimed to determine specific associations...

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Source

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Identifiers

PMID: 25558980
DOI: 10.1038/tpj.2014.79
PMCID: PMC4492912

Genes

FAAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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