Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins.

PloS one - 19 Aug 2009

Brumme Zabrina L, John Mina, Carlson Jonathan M, Brumme Chanson J, Chan Dennison, Brockman Mark A, Swenson Luke C, Tao Iris, Szeto Sharon, Rosato Pamela, Sela Jennifer, Kadie Carl M, Frahm Nicole, Brander Christian, Haas David W, Riddler Sharon A, Haubrich Richard, Walker Bruce D, Harrigan P Richard, Heckerman David, Mallal Simon

Abstract excerpt

BACKGROUND: Despite the extensive genetic diversity of HIV-1, viral evolution in response to immune selective pressures follows broadly predictable mutational patterns. Sites and pathways of Human Leukocyte-Antigen (HLA)-associated polymorphisms in HIV-1 have been identified through the analysis of population-level data, but the full extent of immune escape pathways remains incompletely characterized. Here, in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies
Share to Gene Products, gag

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Products, nef

Share to Gene Products, pol

Share to HIV Infections

Share to HLA Antigens

Share to Immune Evasion

Source

Open in PubMed Open full text

Identifiers

PMID: 19690614
DOI: 10.1371/journal.pone.0006687
PMCID: PMC2723923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins.PMID 19690614Read ↗

Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1.Semantic proximity Read ↗

Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection.Semantic proximity Read ↗

Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1.Semantic proximity Read ↗

HLA-driven convergence of HIV-1 viral subtypes B and F toward the adaptation to immune responses in human populations.Semantic proximity Read ↗

Widespread impact of HLA restriction on immune control and escape pathways of HIV-1.Semantic proximity Read ↗

A strong association of human leukocyte antigen-associated Pol and Gag mutations with clinical parameters in HIV-1 subtype A/E infection.Semantic proximity Read ↗

Increasingly successful highly active antiretroviral therapy delays the emergence of new HLA class I-associated escape mutations in HIV-1.Semantic proximity Read ↗

HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral LoadSemantic proximity Read ↗

HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses.Semantic proximity Read ↗

Identification of HLA class I-associated amino acid polymorphisms in the HIV-1C proteome.Semantic proximity Read ↗

Founder effects in the assessment of HIV polymorphisms and HLA allele associations.Semantic proximity Read ↗

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.