Article
HLA-C downregulation by HIV-1 adapts to host HLA genotype.
PLoS pathogens - 1 Sept 2018
Bachtel Nathaniel D, Umviligihozo Gisele, Pickering Suzanne, Mota Talia M, Liang Hua, Del Prete Gregory Q, Chatterjee Pramita, Lee Guinevere Q, Thomas Rasmi, Brockman Mark A, Neil Stuart, Carrington Mary, Bwana Bosco, Bangsberg David R, Martin Jeffrey N, Kallas Esper G, Donini Camila S, Cerqueira Natalia B, O'Doherty Una T, Hahn Beatrice H, Jones R Brad, Brumme Zabrina L, Nixon Douglas F, Apps Richard
Abstract excerpt
HIV-1 can downregulate HLA-C on infected cells, using the viral protein Vpu, and the magnitude of this downregulation varies widely between primary HIV-1 variants. The selection pressures that result in viral downregulation of HLA-C in some individuals, but preservation of surface HLA-C in others are not clear. To better understand viral immune evasion targeting HLA-C, we have characterized HLA-C downregulation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.