Article
Impaired Nef function is associated with early control of HIV-1 viremia.
Journal of virology - 1 Sept 2014
Kuang Xiaomei T, Li Xiaoguang, Anmole Gursev, Mwimanzi Philip, Shahid Aniqa, Le Anh Q, Chong Louise, Qian Hua, Miura Toshiyuki, Markle Tristan, Baraki Bemuluyigza, Connick Elizabeth, Daar Eric S, Jessen Heiko, Kelleher Anthony D, Little Susan, Markowitz Martin, Pereyra Florencia, Rosenberg Eric S, Walker Bruce D, Ueno Takamasa, Brumme Zabrina L, Brockman Mark A
Abstract excerpt
UNLABELLED: Host and viral factors influence the HIV-1 infection course. Reduced Nef function has been observed in HIV-1 controllers during the chronic phase, but the kinetics and mechanisms of Nef attenuation in such individuals remain unclear. We examined plasma RNA-derived Nef clones from 10 recently infected individuals who subsequently suppressed viremia to less than 2,000 RNA copies/ml within 1 year...
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