Article
Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses.
Virology - 30 Mar 2008
Specht Anke, DeGottardi M Quinn, Schindler Michael, Hahn Beatrice, Evans David T, Kirchhoff Frank
Abstract excerpt
It has been demonstrated that the HIV-1 NL4-3 and IIIB Nef alleles downregulate HLA-A and -B but not -C or -E from the cell surface. It remained elusive, however, whether selective modulation of specific HLA molecules is conserved between different groups of human and simian immunodeficiency viruses, respectively. To address this, we analyzed a large panel of primate lentiviral Nef proteins and we found that this...
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