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Article

HLA-B may be more protective against HIV-1 than HLA-A because it resists negative regulatory factor (Nef) mediated down-regulation.

Proceedings of the National Academy of Sciences of the United States of America - 14 Aug 2012

Rajapaksa Ushani S, Li Demin, Peng Yan-Chun, McMichael Andrew J, Dong Tao, Xu Xiao-Ning

Abstract excerpt

Human leukocyte antigen HLA-B alleles have better protective activity against HIV-1 than HLA-A alleles, possibly due to differences in HLA-restricted HIV-1-specific CD8+ cytotoxic T lymphocyte (CTL) function, but the mechanism is unknown. HIV-1 negative regulatory factor (Nef) mediates down-regulation of surface expression of class I HLA (HLA-I) and may therefore impair immune recognition by CTL. Because of...

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Identifiers

PMID: 22826228
DOI: 10.1073/pnas.1204199109
PMCID: PMC3421200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HLA-B may be more protective against HIV-1 than HLA-A because it resists negative regulatory factor (Nef) mediated down-regulation.PMID 22826228Read ↗

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CTL-mediated selective pressure influences dynamic evolution and pathogenic functions of HIV-1 Nef.Semantic proximity Read ↗

Resistance of Major Histocompatibility Complex Class B (MHC-B) to Nef-Mediated Downregulation Relative to that of MHC-A Is Conserved among Primate Lentiviruses and Influences Antiviral T Cell Responses in HIV-1-Infected Individuals.Semantic proximity Read ↗

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