Article
The Combined Effect of Common Genetic Risk Variants on Circulating Lipoproteins Is Evident in Childhood: A Longitudinal Analysis of the Cardiovascular Risk in Young Finns Study.
PloS one - 1 Jan 2016
Buscot Marie-jeanne, Magnussen Costan G, Juonala Markus, Pitkänen Niina, Lehtimäki Terho, Viikari Jorma S A, Kähönen Mika, Hutri-Kähönen Nina, Schork Nicholas J, Raitakari Olli T, Thomson Russell J
Abstract excerpt
Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) are modifiable risk factors for cardiovascular disease. Several genetic loci for predisposition to abnormal LDL-C, HDL-C and TG have been identified. However, it remains unclear whether these loci are consistently associated with serum lipid levels at each age or with unique developmental...
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