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Genome-wide association study of lipids in Greenlandic Inuit shows independent PCSK9 association and reveals a unique genetic architecture

2023-03-27

Abstract excerpt

<title>Abstract</title> Perturbation of lipid homeostasis is a major risk factor for cardiovascular disease (CVD), the leading cause of death worldwide. We aimed to identify genetic variants affecting lipid levels, and thereby risk of CVD, in Greenlanders. Genome-wide association studies (GWAS) of six blood lipids, triglycerides, LDL-cholesterol, HDL-cholesterol, total cholesterol, as well as apolipoproteins A...

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Literature Corpus work: d57b458d-e64b-5f39-9615-17d825b3784f
DOI: 10.21203/rs.3.rs-2633131/v1

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