Article
Role of Conventional Childhood Risk Factors Versus Genetic Risk in the Development of Type 2 Diabetes and Impaired Fasting Glucose in Adulthood: The Cardiovascular Risk in Young Finns Study.
Diabetes care - 1 Aug 2016
Pitkänen Niina, Juonala Markus, Rönnemaa Tapani, Sabin Matthew A, Hutri-Kähönen Nina, Kähönen Mika, Lehtimäki Terho, Viikari Jorma S A, Raitakari Olli T
Abstract excerpt
OBJECTIVE: We examined whether the addition of novel genetic risk variant data to conventional childhood risk factors improves risk assessment of impaired fasting glucose (IFG) and type 2 diabetes in adulthood. RESEARCH DESIGN AND METHODS: An association of a weighted genetic risk score (wGRS) based on 73 risk variants with IFG and type 2 diabetes was analyzed in 2,298 participants of the Cardiovascular Risk in...
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