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Article

Large-scale genome-wide interaction analyses on multiple cardiometabolic risk factors to identify age-specific genetic risk factors.

GeroScience - 1 Jun 2025

Ao Linjun, van Heemst Diana, Luo Jiao, Teder-Laving Maris, Mägi Reedik, Frikke-Schmidt Ruth, Willems van Dijk Ko, Noordam Raymond

Abstract excerpt

The genetic landscape of cardiometabolic risk factors has been explored extensively. However, insight in the effects of genetic variation on these risk factors over the life course is sparse. Here, we performed genome-wide interaction studies (GWIS) on different cardiometabolic risk factors to identify age-specific genetic risks. This study included 270,276 unrelated European-ancestry participants from the UK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39322921
DOI: 10.1007/s11357-024-01348-0
PMCID: PMC12181146

Genes

TG
APOB
LDLR
PCSK9

Variants

rs11591147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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